Rafeeq Ahmad Mir
Ph.D. - IISER PUNE
Postdoc- Medical Research Council(MRC), UK
MOLECULAR AND CELLULAR NEUROSCIENCE
Parkinson's disease (PD) is the most common cause of neurodegenerative disorder where 90% of PD cases are idiopathic, characterized by chronic inflammation, motor impairment, loss of cognitive activity, presence of typical motor symptoms including bradykinesia, rigidity, resting tremor and abnormal posture. The symptoms are induced by loss of substantia nigra dopamine (DA) neurons with aggregation of α- synuclein in surviving neurons. Our lab focuses on understanding mechanisms underlying Parkinson’s disease (PD) especially interested in identifying novel molecular players and epigenetic modulators to increase our understanding of signaling nexus that may be key in developing the disease and will help in developing better drugs for therapeutic intervention in future. We employ various biochemical and molecular tools along with in vivo system to address these questions.
Sanjeev Galande * Rafeeq Mir * and Ankita Sharma, Epigenetic regulation of the Wnt/ β-catenin signaling pathway in cancer Front. Genet.(2021) doi: 10.3389/fgene.2021.681053
Rafeeq Mir, Francesca Tonelli, Pawel Lis, Thomas Macartney, Nicole K. Polinski, Terina N. Martinez,Meng-Yun Chou, Andrew J.M. Howden, Theresa König, Christoph Hotzy5, Ivan Milenkovic,Thomas Brücke, Alexander Zimprich, Esther Sammler, and Dario R. Alessi. The Parkinson’s disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochemical Journal (2018) 475 1861–1883. Recommended in Faculty Opinions as being of special significance in its field.
Mir R, Sharma A, Pradhan SJ, Galande S. 2018. Regulation of transcription factor SP1 by the β-catenin destruction complex modulates Wnt response. Mol Cell Biol 38:e00188-18. https://doi.org/10.1128/MCB.00188-18.
Mir, R., Pradhan, S.J., Patil, P., Mulherkar, R., and Galande, S. (2015). Wnt / β -catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression. Oncogene. 2015 Jul 13. doi: 10.1038/onc.2015.232. [Epub ahead of print].
Mir, R., Pradhan, S.J., Galande, S. (2012). Chromatin Organizer SATB1 as a Novel Molecular Target for Cancer Therapy. Current Drug Targets, 2012, 13, 1603-1615.