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Centre for Interdisciplinary Research & Innovations
University of Kashmir
9419026757
ciri@uok.edu.in
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RESEARCH
Dr. Altaf Bhat
Publications
Lab Members
Lab Alumni
Funding
Dr. Aijazul Hamid Wani
Dr. Abdul Wajid Bhat
Dr. Rafeeq A. Mir
Dr. Javaid Y. Bhat
Dr. Gulzar Ahmad Bhat
Dr. Aga Shahee
FUNDING
DBT
2019-2020
2020-2021
DST
2019-2020
2020-2021
FIST
2019-2020
2020-2021
PURSE
2019-2020
2020-2021
University of Kashmir
2019-20
2020-21
2021-22
2022-23
ACTIVITIES
DIQA / NAAC
NAAC SSR
Criteria 1
Criteria 1 excel link
Course details
DRC minutes
Criteria 2
Criterion II excel link
Mentorship
2.4.2 Teachers with Ph.D
2.4.4 Teacher Awards
Criteria 3
3.1.4 JRF/SRF
3.2.1 and 3.2.2 Research Funding
3.3.2 Student Awards
3.4.4 Publications
3.4.5 Book Chapters
3.5.1 Revenue Generated
3.6.2 Outreach and extension
Criteria III excel link
Criteria 4
Excel link criteria IV
Laboratories
Research Infrastructure Facilities
Criteria 5
Criteria 6
Criteria VI excel link
certificates
VISITORS
SCHOLARS CORNER
Awarded
Ongoing
Ph.D Course Work
ACHIEVEMENTS
National Academy of Sciences
First Mega Indo-US Research Grant (SPARC)
American Society for Microbiology journal “Molecular and Cellular Biology”
DBT-BUILDER Mega Core Grant
Green Chemistry
Journal of Biological Chemistry
JOBS
08-09-2021
27-07-2022
07-09-2022
19-01-2023
10-04-2023
12-10-2023
18-05-2023
19-06-2023
30-10-2023
15-04-2024
Selected Publications
Home
Selected Publications
Selected Publications:
Mushtaq A, Mir US, Altaf M, Multifaceted functions of RNA binding protein Vigilin in gene silencing, genome stability, and autism related disorders,
Journal of Biological Chemistry (2023)
, doi:
https://doi.org/10.1016/j.jbc.2023.102988
.
Mushtaq A, Ashraf NU, Altaf M. The mTORC1-G9a-H3K9me2 axis negatively regulates autophagy in fatty acid-induced hepatocellular lipotoxicity,
Journal of Biological Chemistry (2023)
Jan 20:102937. doi: 10.1016/j.jbc.2023.102937. Epub ahead of print. PMID: 36690274.
F., Horikoshi, N., Moros, E.G., Guha, D., Hunt, C.R., Makhijani, K., Chau, E., Ahmed, K.M., Sethi, P., Charaka, V., Godin, B., Makhijani, K., Scherthan, H., Deck, J., Hausmann, M.,
Mushtaq, A., Altaf, M
., Ramos, K.S., Bhat, K.M., Taneja, N., Das, C., Pandita, T.K., Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks,
iSCIENCE,
March 21, 2022,
doi.org/10.1016/j.
isci.2022.104142
.
Shah AT, Reshi ZA and
Altaf M
. DNA Methylation of ABC Transporters Differs in Native and Non-native populations of
Conyza canadensis
L.
Frontiers in Ecology and Evolution. 03 February 2022.
S Ahmad, V Cote, X Cheng, G Bourriquen, V Sapountzi,
M Altaf
, J Cote. Antagonistic relationship of NuA4 with the Non-Homologous End- Joining machinery at DNA damage sites.
PLOS GENETICS. 17(9):e1009816, 2021
.
US Mir, A Bhat, A Mushtaq, S Pandita,
M Altaf
, TK Pandita. Role of Histone acetyltransferases MOF and Tip60 in Genome Stability.
DNA Repair. 2021 Aug 8;107:103205.
Banday S, Pandita RK, Mushtaq A, Bacolla A, Mir US, Singh DK, Bhat KP, Hunt CR, Ganesh Rao, Charaka VK, Tainer JA, Pandita TK and
Altaf M
. Autism-associated vigilin
depletion impairs DNA damage repair.
Molecular and Cellular Biology, 23 June 2021.
A Mushtaq, US Mir, CR Hunt, S Pandita, WW Tantray, A Bhat, RK Pandita,
Altaf M
, Pandita TK. Role of Histone Methylation in Maintenance of Genome Integrity.
Genes. 2021. PMID: 34209979.
S Nisar, RA Dar,
Altaf M
, Z Farooq, I Tahir. Some important biochemical changes orchestrating flower development and senescence in
Nicotiana plumbaginifolia
Viv. and
Petunia hybrida
Vilm. flowers,.
The Journal of Horticultural Science and Biotechnology, 1-11, 2021.
Farooq Z, Abdullah E, Banday S, Ganai SA, Rashid R, Mushtaq M, Rashid S and
Altaf M
. Vigilin protein Vgl1 is required for heterochromatin mediated gene silencing.
Journal of Biological Chemistry,
Sep 26, 2019.
Ganai SA, Abdullah E, Rashid R,
Altaf M
. Combinatorial
In Silico
Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective Chemotherapy against Neurological Disorders.
Frontiers in Molecular Neuroscience
. 2017 Nov 9;10:357.
Nissar U Ashraf and
Mohammad Altaf
. Epigenetics: an emerging field in the pathogenesis of nonalcoholic fatty liver disease.
Mutation Research Reviews,
Volume 778, October–December 2018, Pages 1-12.
Banday S, Farooq Z, Rashid R and
Altaf M
. Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing.
Journal of Biological Chemistry.
Sep 16;291(38):20021-9.
Ganai SA, Banday S, Farooq Z,
Altaf M.
Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders.
Pharmacology and Therapeutics
2016
Jul 10. pii: S0163-7258(16)30110-3.
Farooq Z, Banday S, Pandita TK and
Altaf M
. The many faces of histone H3K79 methylation.
Mutation Research Reviews,
2016
Apr-Jun; 768:46-52.
Cheng X, Auger A,
Altaf M
, Drouin S, Paquet E, Utley R, Robert F and Jacques Cote. Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis.
Eukaryotic Cell,
14, 535-44, 2015
Wang F, Li G,
Altaf M
, Lu C, Curie MA, Johnson A and Moazed D. Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA.
Proc Natl Acad Sci U SA
. May 21; 110(21): 8495-500,2013.
Nnakwe CC,
Altaf M
, Côté J, Kron SJ. Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.
DNA Repair
2009 Dec 3;8(12):1452-61.
Altaf M
, Auger A,Monnet-Saksouk J, Brodeur J,Piquet S,Cramet M, Bouchard N,Lacoste N,Utley RT,Gaudreau L,Côté J. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.
Journal of Biological Chemistry.
2010 May 21;285(21):15966-77
Auger A, Galarneau L ,
Altaf M,
Nourani A, Doyon Y, Utley RT, Cronier D, Allard S and Côté J. Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants.
Molecular and Cellular Biology.
2008 Apr; 28(7):2257.
Altaf M
, Utley RT,Lacoste N,Tan S,Briggs SD,Côté J. Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin.
Molecular Cell.
2007 Dec 28; 28(6):1002-14.
Ali Javaheri, Robert Wysocki, Olivier Jobin-Robitaille,
Altaf M
, Jacques Cote and Stephen J. Kron Yeast G1DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling.
The Proceedings of the National Academy of Sciences USA.
2006
Sep 12;103(37):13771.
Shravanti Rampalli, L. Pavithra,
Altaf Bhat
, Tapas K. Kundu, and Samit Chattopadhyay. Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.
Molecular and Cellular Biology
.2005
October; 25(19): 8415–8429.
Balasubramanyam K,
Altaf M,
Varier RA, Swaminathan V, Siddappa NB, Ranga U, Kundu TK. Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of acetyltransferase, represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription
.
Journal of Biological Chemistry
.
2004 Dec 3; 279(49): 51163-71.
Balasubramanyam K,
Altaf M,
Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression
.
Journal of Biological Chemistry
. 2004Aug 6; 279(32): 33716-26.
Patents:
Karanam Balasubramanyam,
Altaf, M
., Lingu M, Radhika, A.V., Swaminathan, V and Kundu T.K. (2003). Polyisoprenylated benzophenones and their isomers as inhibitors of Histone acetyltransferases and uses thereof.
No: 929/CHE/2003.
Balasubramanyam, K., Swaminathan, V,
Altaf M
, Radhika. A. V and Kundu, T.K. Use of curcumanoids a Histone acetyltransferases (HATs) inhibitors.
IPN: 544/CHE/2004.
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